 | | Tennessee Tech | 78 | | 7-10 |  | | Austin Peay | 51 | | 8-10 | | Mar 2, 2022 7:00 PM | |  | | SIU Edwardsville | 62 | | 4-12 |  | | Tennessee St. | 77 | | 8-10 | | Mar 2, 2022 7:00 PM | |
| | | Tennessee St. | 55 | | 8-10 |  | | Southeast Missouri St. | 79 | | 7-9 | | Mar 3, 2022 7:30 PM | | | | Tennessee Tech | 56 | | 7-10 |  | | Morehead State | 73 | | 12-5 | | Mar 3, 2022 10:00 PM | |
| | | Southeast Missouri St. | 67 | | 7-9 |  | 20 | Murray State | 71 | | 17-0 | | Mar 4, 2022 8:00 PM | | | | Morehead State | 53 | | 12-5 |  | | Belmont | 51 | | 15-3 | | Mar 4, 2022 10:30 PM | |
| | | Morehead State | 67 | | 12-5 | | 20 | Murray State | 71 | | 17-0 | | Mar 5, 2022 7:00 PM | |
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